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Article

Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction.

Endocrinology - 1 Aug 2007

Barrett Perry, Ebling Francis J P, Schuhler Sandrine, Wilson Dana, Ross Alexander W, Warner Amy, Jethwa Preeti, Boelen Anita, Visser Theo J, Ozanne Daniel M, Archer Zoe A, Mercer Julian G, Morgan Peter J

Abstract excerpt

Seasonal adaptations in physiology exhibited by many animals involve an interface between biological timing and specific neuroendocrine systems, but the molecular basis of this interface is unknown. In this study of Siberian hamsters, we show that the availability of thyroid hormone within the hypothalamus is a key determinant of seasonal transitions. The expression of the gene encoding type III deiodinase (Dio3)...

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Source

Identifiers

PMID: 17478556
DOI: 10.1210/en.2007-0316

Genes

DIO3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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