Article
A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array.
BMC bioinformatics - 3 May 2007
Yu Tianwei, Ye Hui, Sun Wei, Li Ker-Chau, Chen Zugen, Jacobs Sharoni, Bailey Dione K, Wong David T, Zhou Xiaofeng
Abstract excerpt
BACKGROUND: DNA copy number aberration (CNA) is one of the key characteristics of cancer cells. Recent studies demonstrated the feasibility of utilizing high density single nucleotide polymorphism (SNP) genotyping arrays to detect CNA. Compared with the two-color array-based comparative genomic hybridization (array-CGH), the SNP arrays offer much higher probe density and lower signal-to-noise ratio at the single...
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