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Article

Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice.

The EMBO journal - 15 Dec 2000

Deans B, Griffin C S, Maconochie M, Thacker J

Abstract excerpt

Repair of DNA damage by homologous recombination has only recently been established as an important mechanism in maintaining genetic stability in mammalian cells. The recently cloned Xrcc2 gene is a member of the mammalian Rad51 gene family, thought to be central to homologous recombination repair. To understand its function in mammals, we have disrupted Xrcc2 in mice. No Xrcc2(-/-) animals were found alive, with...

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Identifiers

PMID: 11118202
DOI: 10.1093/emboj/19.24.6675
PMCID: PMC305908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice.PMID 11118202Read ↗

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