Article
Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.
PloS one - 1 Jan 2013
Rodrigues Paulo M G, Grigaravicius Paulius, Remus Martina, Cavalheiro Gabriel R, Gomes Anielle L, Rocha-Martins Maurício, Martins Mauricio R, Frappart Lucien, Reuss David, McKinnon Peter J, von Deimling Andreas, Martins Rodrigo A P, Frappart Pierre-Olivier
Abstract excerpt
Nibrin (NBN or NBS1) and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivity, neurological developmental defects and cancer predisposition. However, the functional synergy of Nbn and Atm in different tissues and developmental stages is not...
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