Article
Genetic polymorphisms in Plasmodium falciparum chloroquine resistance genes, pfcrt and pfmdr1, in North Sulawesi, Indonesia.
BMC research notes - 4 Apr 2017
Reteng Patrick, Vrisca Visia, Sukarno Inka, Djarkoni Ilham Habib, Kalangi Jane Angela, Jacobs George Eduardo, Runtuwene Lucky Ronald, Eshita Yuki, Maeda Ryuichiro, Suzuki Yutaka, Mongan Arthur Elia, Warouw Sarah Maria, Yamagishi Junya, Tuda Josef
Abstract excerpt
BACKGROUND: Malaria still poses one of the major threats to human health. Development of effective antimalarial drugs has decreased this threat; however, the emergence of drug-resistant Plasmodium falciparum, a cause of Malaria, is disconcerting. The antimalarial drug chloroquine has been effecti...
Topics
- Antimalarials
- Chloroquine
- DNA, Protozoan
- Drug Resistance
- Drug Resistance, Multiple
- Gene Frequency
- Genotype
- Geography
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Indonesia
- Malaria, Falciparum
- Membrane Transport Proteins