Article
Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda.
Hepatology (Baltimore, Md.) - 1 Feb 2001
Sinclair P R, Gorman N, Walton H S, Bement W J, Sinclair J F, Gerhard G S, Szakacs J G, Andrews N C, Levy J E
Abstract excerpt
Porphyria cutanea tarda (PCT), a liver disease with skin lesions caused by excess liver production of uroporphyrin (URO), is associated with consumption of alcoholic beverages or estrogens, and moderate iron overload. Recently, it has been shown that many PCT patients carry mutations in the HFE gene, which is responsible for hereditary hemochromatosis. Mice homozygous for either the null mutation in the Hfe gene...
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