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Article

hTERT transcription is repressed by Cbfa1 in human mesenchymal stem cell populations.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2007

Isenmann Sandra, Cakouros Dimitrios, Zannettino Andrew, Shi Songtao, Gronthos Stan

Abstract excerpt

UNLABELLED: Human BMSSCs lose telomerase activity in vitro, which leads to chromosomal instability and cellular senescence. We observed an inverse expression pattern between the osteogenic master regulatory gene, CBFA1, and the stem cell-associated gene, hTERT. We showed that Cbfa1 acts as a partial repressor of TERT, which may facilitate cellular differentiation. INTRODUCTION: The absence of telomerase activity...

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Identifiers

PMID: 17352650
DOI: 10.1359/jbmr.070308

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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