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<i>TUP1</i> disruption in <i>Cryptococcus neoformans</i> uncovers a peptide‐mediated density‐dependent growth phenomenon that mimics quorum sensing

24 Apr 2007

Abstract excerpt

Cryptococcus neoformans is a pathogenic yeast that causes life-threatening meningoencephalitis and grows well on mycological media regardless of inoculum size. Interestingly, a deletion of the global repressor TUP1 in C. neoformans uncovered a density-dependent growth phenotype reminiscent of the quorum-sensing phenomenon. An inoculum size of lower than 10(3) cells of the tup1Delta strain failed to form colonies...

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PMID: 17462010
DOI: 10.1111/j.1365-2958.2007.05666.x

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<i>TUP1</i> disruption in <i>Cryptococcus neoformans</i> uncovers a peptide‐mediated density‐dependent growth phenomenon that mimics quorum sensingPMID 17462010Read ↗

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