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Article

Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia.

Journal of thrombosis and haemostasis : JTH - 1 May 2007

Castoldi E, Simioni P, Tormene D, Thomassen M C L G D, Spiezia L, Gavasso S, Rosing J

Abstract excerpt

BACKGROUND: Hyperprothrombinemia, resulting from the prothrombin G20210A mutation or other causes, is associated with activated protein C (APC) resistance and increased thrombosis risk. When high prothrombin levels are a result of increased hepatic biosynthesis, these effects may be counteracted by concomitantly increased levels of the anticoagulant factors (particularly protein S). Differently, in prothrombin...

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PMID: 17461930
DOI: 10.1111/j.1538-7836.2007.02448.x

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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