Article
Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype.
Thrombosis and haemostasis - 1 Sept 2023
Natorska Joanna, Corral Javier, de la Morena-Barrio Maria Eugenia, Bravo-Pérez Carlos, Bagoly Zsuzsa, Bereczky Zsuzsanna, Treliński Jacek, Witkowski Michał, Klajmon Adrianna, Undas Anetta, Ząbczyk Michał
Abstract excerpt
BACKGROUND: Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function. METHODS: We evaluated 148 patients (age: 38 [32-50] years; 70% women) with genetically confirmed antithrombin deficiency and 50 healthy controls. Fibrin clot permeability (Ks) and clot lysis time (CLT) along with thrombin generation capacity were...
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