Article
Molecular pathophysiology of thrombotic states and their impact to laboratory diagnostics.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Mar 2009
Slavik Ludek, Krcova Vera, Hlusi Antonin, Prochazkova Jana, Prochazka Martin, Ulehlova Jana, Indrak Karel
Abstract excerpt
BACKGROUND: Molecular genetic methods were implemented in the detection of thrombophilic disorders in the 1990's with the discovery of coagulation inhibitors antithrombin III (AT III), protein C (PC) and S (PS). The discovery of the molecular cause of activated protein C (APC) resistance by Bertina in 1994 greatly expanded their utilization. METHODS AND RESULTS: Currently, a broad group of molecular genetic...
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