Article
The origin of phenotypic heterogeneity in a clonal cell population in vitro.
PloS one - 25 Apr 2007
Stockholm Daniel, Benchaouir Rachid, Picot Julien, Rameau Philippe, Neildez Thi My Anh, Landini Gabriel, Laplace-Builhé Corinne, Paldi Andras
Abstract excerpt
BACKGROUND: The spontaneous emergence of phenotypic heterogeneity in clonal populations of mammalian cells in vitro is a rule rather than an exception. We consider two simple, mutually non-exclusive models that explain the generation of diverse cell types in a homogeneous population. In the first model, the phenotypic switch is the consequence of extrinsic factors. Initially identical cells may become different...
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