MAFB Overexpression in Macrophages Promotes Wound Healing in Diabetic Foot Ulcer by Transcriptionally Activating WDR74 to Drive a Tissue-Repair Phenotype and Suppress Inflammation and Oxidative Stress.

doi:10.1007/s12010-026-05771-1

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MAFB Overexpression in Macrophages Promotes Wound Healing in Diabetic Foot Ulcer by Transcriptionally Activating WDR74 to Drive a Tissue-Repair Phenotype and Suppress Inflammation and Oxidative Stress.

Applied biochemistry and biotechnology - 1 Oct 2026

Lin Hai, Cai Qi, Wang Tingting, Zheng Li, Yu Meizhen, Wen Yinwei

Abstract excerpt

Diabetic foot ulcer (DFU) represents a significant challenge in clinical management due to its complexity and the impaired wound-healing process associated with diabetes. The role of MAF bZIP transcription factor B (MAFB) in regulating macrophage polarization and its potential impact on DFU healing is an area of growing interest. This study investigates the molecular mechanisms by which MAFB influences diabetic...

Read the complete abstract on PubMed

Topics

Animals
Oxidative Stress
Wound Healing
Macrophages
MafB Transcription Factor
Rats

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Inflammation

Diabetic Foot

Mice

Rats, Sprague-Dawley

Male

Transcriptional Activation

Phenotype

RAW 264.7 Cells

Source

Open in PubMed

Identifiers

PMID: 42360661
DOI: 10.1007/s12010-026-05771-1

Genes

MAFB
CD86
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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