Article
Influence of interleukin-1beta gene polymorphisms on age-at-onset of sporadic Parkinson's disease.
Neuroscience letters - 21 Apr 2000
Nishimura M, Mizuta I, Mizuta E, Yamasaki S, Ohta M, Kuno S
Abstract excerpt
We studied genetic polymorphisms in the promoter region (position -511) and exon 5 (position +3953) of the interleukin (IL)-1beta gene in 122 Japanese patients with Parkinson's disease (PD) and 112 controls. We also examined polymorphisms in the IL-1alpha and the IL-1 receptor antagonist genes. No significant difference was found in these genetic markers between PD patients and controls. However, PD patients with...
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