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Article

IGFBp-3 prolongs the p53 response and enhances apoptosis following UV irradiation

1 Jan 2000

Abstract excerpt

Neoplastic transformation is characterised by an imbalance in favour of cell growth over programmed cell death (apoptosis). The tumour-suppressor gene p53, responsible for maintaining cell-cycle control, is mutated in the majority of human cancers. Loss of function of the target genes of p53 are therefore important in tumourigenesis. One such target gene is the insulin-like growth factor binding protein-3...

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PMID: 11054660
DOI: 10.1002/1097-0215(20001101)88:3<336::aid-ijc3>3.0.co;2-a

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