Article
IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis.
Human immunology - 1 Jul 2010
Vallinoto Antonio C R, Graça Ednelza S, Araújo Mauro S, Azevedo Vânia N, Cayres-Vallinoto Izaura, Machado Luiz Fernando A, Ishak Marluisa O G, Ishak Ricardo
Abstract excerpt
Regarding the importance of interferon-gamma (IFN-gamma) in protective immunity against Mycobacterium tuberculosis and the functional role of IFNG +874T/A single nucleotide polymorphism (SNP) in the IFN-gamma production, the present study investigated the relationship of this genetic polymorphism with susceptibility to tuberculosis (TB). A total of 129 patients with pulmonary tuberculosis (PTB), 33 with...
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