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Article

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2007

Chorbov Vesselin M, Lobos Elizabeth A, Todorov Alexandre A, Heath Andrew C, Botteron Kelly N, Todd Richard D

Abstract excerpt

Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5-HTT) in the development of mood disorders. In the present study of a sample of 247 young adult female twins from Missouri, we examine whether this polymorphism interacts with the effect of adverse life events to increase risk for developing depression. We found a significant...

Topics

Adolescent
Adult
Alleles
Depressive Disorder, Major
Female
Genotype
Humans
Prospective Studies
Risk Factors
Serotonin Plasma Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17455215
DOI: 10.1002/ajmg.b.30534

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17455215-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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