Article
Glutathione-S-transferase genotypes influence prognosis in follicular non-Hodgkin's Lymphoma.
Leukemia & lymphoma - 1 Mar 2007
Hohaus Stefan, Mansueto Giovanna, Massini Giuseppina, D'Alo Francesco, Giachelia Manuela, Martini Maurizio, Larocca Luigi Maria, Voso Maria Teresa, Leone Giuseppe
Abstract excerpt
Polymorphisms in detoxification enzymes of the glutathione S-transferase (GST) family have been associated with risk and prognosis of several cancer types. We studied deletions of GSTM1 and GSTT1, and the GSTP1 Ile(105)Val polymorphism in 89 patients with follicular lymphoma (FL). Patients with a GSTM1 or GSTT1 deletion had a significantly worse event-free survival, when compared with patients with undeleted...
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