Article
The positively charged residues in the fragment 71 - 77 of complexin is required for its binding to SNARE complex.
IUBMB life - 1 Feb 2007
Liu Jingguo, Wei Yong, Guo Ting, Xie Xin, Jiang Jiansen, Sui Sen-fang
Abstract excerpt
Complexin is a cytoplasmic protein that plays an important role in the neurotransmitters release triggered by action potential. Previous studies suggested that complexin performs its functions through interaction with the SNARE complex. The crystal structure of complexin/SNARE complex revealed that complexin binds to SNARE core complex in an anti-parallel conformation with its residues 48 - 70. However, the...
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