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Article

A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha.

The Journal of biological chemistry - 2 Sept 2011

Xue Zhen, He Yin, Ye Kaixiong, Gu Zhenglong, Mao Yuxin, Qi Ling

Abstract excerpt

Inositol-requiring enzyme 1α (IRE1α), an endoplasmic reticulum-resident sensor for mammalian unfolded protein response, is a bifunctional enzyme containing kinase and RNase domains critical for trans-autophosphorylation and Xbp1 mRNA splicing, respectively, in response to endoplasmic reticulum stress. However, the amino acid residues important for its function and activation remain largely unexplored. Here,...

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Identifiers

PMID: 21757700
DOI: 10.1074/jbc.M111.273714
PMCID: PMC3162446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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