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Article

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.

Nucleic acids research - 1 Jan 2007

Wanrooij Sjoerd, Goffart Steffi, Pohjoismäki Jaakko L O, Yasukawa Takehiro, Spelbrink Johannes N

Abstract excerpt

The mechanism of mitochondrial DNA replication is a subject of intense debate. One model proposes a strand-asynchronous replication in which both strands of the circular genome are replicated semi-independently while the other model proposes both a bidirectional coupled leading- and lagging-strand synthesis mode and a unidirectional mode in which the lagging-strand is initially laid-down as RNA by an unknown...

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Share to Catalytic Domain
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to DNA, Mitochondrial

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Share to Electrophoresis, Gel, Two-Dimensional

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Source

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Identifiers

PMID: 17452351
DOI: 10.1093/nar/gkm215
PMCID: PMC1904276

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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