Three common TP53 polymorphisms in susceptibility to breast cancer, evidence from meta-analysis.

doi:10.1007/s10549-009-0488-9

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Article

Three common TP53 polymorphisms in susceptibility to breast cancer, evidence from meta-analysis.

Breast cancer research and treatment - 1 Apr 2010

Hu Zheng, Li Xiang, Yuan Rong, Ring Brian Z, Su Li

Abstract excerpt

The association of polymorphisms of tumor suppressor gene TP53 with breast cancer has widely been reported; however, the results are inconsistent. Here, we selected three commonly studied TP53 polymorphisms: codon 72 Arg > Pro, IVS3 16 bp Del/Ins, and IVS6 + 62A > G to explore their association with breast cancer risk by meta-analysis of published case-control studies. The results showed that codon 72 was not...

Topics

Adult
Aged
Aged, 80 and over
Asia
Breast Neoplasms
Case-Control Studies
Codon
Europe
Female
Genes, p53
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mediterranean Region

Middle Aged

Mutagenesis, Insertional

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Risk

Source

Open in PubMed

Identifiers

PMID: 19657731
DOI: 10.1007/s10549-009-0488-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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