Article
Association of common WRAP 53 variant with ovarian cancer risk in the Polish population.
Molecular biology reports - 1 Mar 2013
Mędrek Krzysztof, Magnowski Piotr, Masojć Bartłomiej, Chudecka-Głaz Anita, Torbe Bogdan, Menkiszak Janusz, Spaczyński Marek, Gronwald Jacek, Lubiński Jan, Górski Bohdan
Abstract excerpt
Among many alterations within the TP53 gene the rs1042522 (C72G, p.Pro72Arg) has been associated with numerous cancers , however the results differ between populations for opposite Pro or Arg alleles. Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogenesis directly, but might be linked to another pathogenic alteration. WRAP53...
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