Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer.

doi:10.3892/or_00000556

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Article

Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer.

Oncology reports - 1 Nov 2009

Hrstka Roman, Beranek Michal, Klocova Katerina, Nenutil Rudolf, Vojtesek Borivoj

Abstract excerpt

Recent studies have suggested that genetic polymorphisms in the TP53 pathway influence tumour formation, progression and response to therapy. We analysed the three most common TP53 gene polymorphisms as potential genetic markers to predict the development and prognosis of breast cancer. The incidence of R72P, PIN3 Ins 16bp and PIN6 G13494A polymorphisms was determined in a cohort of 117 breast cancer tissues and...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Breast
Breast Neoplasms
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Female
Gene Frequency
Humans
Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Introns

Lymphatic Metastasis

Middle Aged

Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 19787241
DOI: 10.3892/or_00000556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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