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Article

A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease.

Neurology - 26 Sept 2000

Crawford F C, Freeman M J, Schinka J A, Abdullah L I, Gold M, Hartman R, Krivian K, Morris M D, Richards D, Duara R, Anand R, Mullan M J

Abstract excerpt

OBJECTIVE: To investigate whether or not a coding polymorphism in the cystatin C gene (CST3) contributes risk for AD. DESIGN: A case-control genetic association study of a Caucasian dataset of 309 clinic- and community-based cases and 134 community-based controls. RESULTS: The authors find a signficant interaction between the GG genotype of CST3 and age/age of onset on risk for AD, such that in the over-80 age...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10993992
DOI: 10.1212/wnl.55.6.763

Genes

APOE
CST3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease.PMID 10993992Read ↗

Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease.Semantic proximity Read ↗

Cystatin C as a risk factor for Alzheimer disease.Semantic proximity Read ↗

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The association of a cystatin C gene polymorphism with late-onset Alzheimer's disease and vascular dementia.Semantic proximity Read ↗

Meta-analysis of the cystatin C(CST3) gene G73A polymorphism and susceptibility to Alzheimer's disease.Semantic proximity Read ↗

Cystatin C and apoe polymorphisms in Italian Alzheimer's disease.Semantic proximity Read ↗

Genotype and plasma concentration of cystatin C in patients with late-onset Alzheimer disease.Semantic proximity Read ↗

Effects of CST3 Gene G73A Polymorphism on Cystatin C in a Prospective Multiethnic Cohort Study.Semantic proximity Read ↗

Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease.Semantic proximity Read ↗

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The CST3 B haplotype is associated with frontotemporal lobar degeneration.Semantic proximity Read ↗

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