Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4.

Nucleic acids research - 1 Jan 2007

Ohn Takbum, Chiang Yueh-Chin, Lee Darren J, Yao Gang, Zhang Chongxu, Denis Clyde L

Abstract excerpt

The CAF1 protein is a component of the CCR4-NOT deadenylase complex. While yeast CAF1 displays deadenylase activity, this activity is not required for its deadenylation function in vivo, and CCR4 is the primary deadenylase in the complex. In order to identify CAF1-specific functional regions required for deadenylation in vivo, we targeted for mutagenesis six regions of CAF1 that are specifically conserved among...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to Gene Deletion
Share to Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Poly A

Share to Polyadenylation

Share to Ribonucleases

Share to RNA, Messenger

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17439972
DOI: 10.1093/nar/gkm196
PMCID: PMC1888822

Genes

CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4.PMID 17439972Read ↗

A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila.Semantic proximity Read ↗

Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Ccr4-Not complex interacts with the mRNA export machinery.Semantic proximity Read ↗

Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.Semantic proximity Read ↗

Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.Semantic proximity Read ↗

The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses.Semantic proximity Read ↗

Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal.Semantic proximity Read ↗

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complexSemantic proximity Read ↗

The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control.Semantic proximity Read ↗

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.Semantic proximity Read ↗

Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1Semantic proximity Read ↗

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.