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Article

Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal.

The Journal of biological chemistry - 4 Jun 2004

Viswanathan Palaniswamy, Ohn Takbum, Chiang Yueh-Chin, Chen Junji, Denis Clyde L

Abstract excerpt

The mouse CAF1 (mCAF1) is an ortholog of the yeast (y) CAF1 protein, which is a component of the CCR4-NOT complex, the major cytoplasmic deadenylase of Saccharomyces cerevisiae. Although CAF1 protein belongs to the DEDDh family of RNases, CCR4 appears to be the principle deadenylase of the CCR4-N...

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Source

Identifiers

PMID: 15044470
DOI: 10.1074/jbc.M402803200

Genes

CCR4
DEDD
PAN2
PARN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15044470-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal.PMID 15044470Read ↗

A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila.Semantic proximity Read ↗

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complexSemantic proximity Read ↗

Molecular Insights into mRNA Polyadenylation and DeadenylationSemantic proximity Read ↗

CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4.Semantic proximity Read ↗

Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAsSemantic proximity Read ↗

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainSemantic proximity Read ↗

CCR4-NOT complex nuclease Caf1 is a novel shuttle factor involved in the degradation of ubiquitin-modified proteins by 26S proteasomeSemantic proximity Read ↗

Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.Semantic proximity Read ↗

Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses.Semantic proximity Read ↗

The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell ProliferationSemantic proximity Read ↗

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.Semantic proximity Read ↗

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