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Article

Destabilised mutants of ubiquitin gain equal stability in crowded solutions.

Biophysical chemistry - 1 Jul 2007

Roberts Andrew, Jackson Sophie E

Abstract excerpt

This paper investigates the thermodynamic and kinetic response of WT* ubiquitin (F45W) and three mutants to high concentrations of glucose, sucrose and dextran under physiological temperature and pH. WT* ubiquitin was stabilised by the same amount when comparing each cosolute on a weight to volume ratio, with cosolute effects largely independent of denaturant concentration. The energy difference between the...

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Identifiers

PMID: 17434659
DOI: 10.1016/j.bpc.2007.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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