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Article

Mechanism of protein kinetic stabilization by engineered disulfide crosslinks.

PloS one - 1 Jan 2013

Sanchez-Romero Inmaculada, Ariza Antonio, Wilson Keith S, Skjøt Michael, Vind Jesper, De Maria Leonardo, Skov Lars K, Sanchez-Ruiz Jose M

Abstract excerpt

The impact of disulfide bonds on protein stability goes beyond simple equilibrium thermodynamics effects associated with the conformational entropy of the unfolded state. Indeed, disulfide crosslinks may play a role in the prevention of dysfunctional association and strongly affect the rates of irreversible enzyme inactivation, highly relevant in biotechnological applications. While these kinetic-stability...

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Identifiers

PMID: 23936134
DOI: 10.1371/journal.pone.0070013
PMCID: PMC3728334

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Source receipt: pubmed, retrieved 7 Sept 2026.

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