Article
Alpha-fetoprotein gene polymorphisms and risk of HCC and cirrhosis.
Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2010
Suriapranata Ivet M, Sudania Widyartini Made, Tjong Wen Ye, Suciptan Adi A, Gani Rino A, Hasan Irsan, Sanityoso Andri, Budihusodo Unggul, Miskad Upik A, Akil Fardah, Lelosutan Syafruddin A R, Martamala Ruswhandi, Yusuf Irawan, Lesmana Laurentius A, Sulaiman Ali, Tai Susan
Abstract excerpt
BACKGROUND: Elevated level of alpha fetoprotein (AFP) is found in approximately 60% of hepatocellular carcinoma (HCC) cases. Other liver diseases including cirrhosis and chronic hepatitis are related with an increased level of AFP. The regulation of AFP gene expression has been relatively less studied although the gene has been suggested to play a role in HCC development. This study aimed at identifying genetic...
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