Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biology and significance of alpha‐fetoprotein in hepatocellular carcinoma

22 Aug 2019

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths globally due, in part, to the majority of patients being diagnosed with intermediate or advanced stage disease. Our increased understanding of the heterogeneous molecular pathogenesis of HCC has led to significant developments in novel targeted therapies. Despite these advances, there remains a high unmet need for new...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Hepatocellular Carcinoma Treatment and Prognosis
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31436873
DOI: 10.1111/liv.14223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biology and significance of alpha‐fetoprotein in hepatocellular carcinomaPMID 31436873Read ↗

Alpha-fetoprotein: Past, present, and futureSemantic proximity Read ↗

Hepatocellular Carcinoma: Causes, Mechanism of Progression and BiomarkersSemantic proximity Read ↗

High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations.Semantic proximity Read ↗

Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trialsSemantic proximity Read ↗

Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-κB (P65) Pathway in Hepatocellular Carcinoma CellsSemantic proximity Read ↗

Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics.Semantic proximity Read ↗

miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells.Semantic proximity Read ↗

Advances in Histological and Molecular Classification of Hepatocellular CarcinomaSemantic proximity Read ↗

Preoperative alpha-fetoprotein (AFP) in hepatocellular carcinoma (HCC): is this 50-year biomarker still up-to-date?Semantic proximity Read ↗

HBP1-mediated transcriptional regulation of AFP and its impact on hepatomaSemantic proximity Read ↗

Proteomic signature corresponding to alpha fetoprotein expression in liver cancer cellsSemantic proximity Read ↗

HBP1-mediated transcriptional repression of AFP inhibits hepatoma progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.