Article
A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity.
The Journal of physiology - 15 Jun 2007
Sheets Patrick L, Jackson James O, Waxman Stephen G, Dib-Hajj Sulayman D, Cummins Theodore R
Abstract excerpt
Mutations in the TTX-sensitive voltage-gated sodium channel subtype Nav1.7 have been implicated in the painful inherited neuropathy, hereditary erythromelalgia. Hereditary erythromelalgia can be difficult to treat and, although sodium channels are targeted by local anaesthetics such as lidocaine...
Topics
- Action Potentials
- Anesthetics, Local
- Binding Sites
- Cell Line
- Computer Simulation
- Dose-Response Relationship, Drug
- Erythromelalgia
- Ganglia, Spinal
- Humans
- Ion Channel Gating
- Kinetics