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Article

Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.

Experimental neurology - 1 Apr 2009

Choi Jin-Sung, Zhang Lili, Dib-Hajj Sulayman D, Han Chongyang, Tyrrell Lynda, Lin Zhimiao, Wang Xiaoliang, Yang Yong, Waxman Stephen G

Abstract excerpt

Inherited erythromelalgia (IEM), characterized by episodic burning pain and erythema of the extremities, is produced by gain-of-function mutations in sodium channel Na(v)1.7, which is preferentially expressed in nociceptive and sympathetic neurons. Most patients do not respond to pharmacotherapy, although occasional reports document patients as showing partial relief with lidocaine or mexiletine. A 7-year-old...

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PMID: 19162012
DOI: 10.1016/j.expneurol.2008.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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