Article
Inverse relationship between the length of the EGFR CA repeat polymorphism in lung carcinoma and protein expression of EGFR in the carcinoma.
Journal of surgical oncology - 1 Nov 2008
Suzuki Masaya, Kageyama Shinji, Shinmura Kazuya, Okudela Koji, Bunai Tomoyasu, Nagura Kiyoko, Igarashi Hisaki, Kiyose Shinichiro, Mori Hiroki, Tao Hong, Goto Masanori, Takamochi Kazuya, Mochizuki Takahiro, Suzuki Kazuya, Ohashi Riuko, Ogawa Hiroshi, Yamada Takeshi, Niwa Hiroshi, Tsuneyoshi Toshihiro, Sugimura Haruhiko
Abstract excerpt
BACKGROUND AND OBJECTIVES: There is a CA dinucleotide repeat polymorphism in the first intron of the epidermal growth factor receptor (EGFR) gene. Our aim was to examine the relationship between the CA repeat length in lung carcinoma and EGFR mutation, EGFR gene copy number, and EGFR protein expression level in the carcinoma. METHODS: We examined 168 lung carcinomas for the length of the CA repeat polymorphism by...
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