The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.

doi:10.1016/s0092-8674(02)00677-3

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Article

The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.

Cell - 5 Apr 2002

Zhou Qiao, Anderson David J

Abstract excerpt

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest that Olig1(-/-)2(-/-) pMN progenitors instead generate V2 interneurons and then...

Topics

Animals
Astrocytes
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation
Cell Lineage
DNA-Binding Proteins
Female
Helix-Loop-Helix Motifs
Homeodomain Proteins
Interneurons
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Motor Neurons

Mutation

Nerve Tissue Proteins

Neuroglia

Neurons

Source

Open in PubMed

Identifiers

PMID: 11955447
DOI: 10.1016/s0092-8674(02)00677-3

Genes

OLIG1
OLIG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.PMID 11955447Read ↗

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