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Article

The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.

Cell - 5 Apr 2002

Zhou Qiao, Anderson David J

Abstract excerpt

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest that Olig1(-/-)2(-/-) pMN progenitors instead generate V2 interneurons and then...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11955447
DOI: 10.1016/s0092-8674(02)00677-3

Genes

OLIG1
OLIG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.PMID 11955447Read ↗

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bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNSSemantic proximity Read ↗

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Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling.Semantic proximity Read ↗

A critical role for dorsal progenitors in cortical myelination.Semantic proximity Read ↗

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