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Article

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

16 Dec 2004

Abstract excerpt

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in...

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PMID: 15604411
DOI: 10.1126/science.1103709

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Related research

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Research trail→

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bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNSPMID 15604411Read ↗

Olig1 function is required for oligodendrocyte differentiation in the mouse brain.Semantic proximity Read ↗

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.Semantic proximity Read ↗

<i>Olig</i> gene function in CNS development and diseaseSemantic proximity Read ↗

Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice.Semantic proximity Read ↗

The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.Semantic proximity Read ↗

Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.Semantic proximity Read ↗

Gain of Olig2 function in oligodendrocyte progenitors promotes remyelinationSemantic proximity Read ↗

Oligodendrocyte lineage genes ( <i>OLIG</i> ) as molecular markers for human glial brain tumorsSemantic proximity Read ↗

A crucial role for Olig2 in white matter astrocyte development.Semantic proximity Read ↗

Prox1 Inhibits Proliferation and Is Required for Differentiation of the Oligodendrocyte Cell Lineage in the MouseSemantic proximity Read ↗

Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specificationSemantic proximity Read ↗

Promoting Myelin Repair through In Vivo Neuroblast Reprogramming.Semantic proximity Read ↗

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