Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse.

Diabetes - 1 Jul 2007

Goodarzi Mark O, Lehman Donna M, Taylor Kent D, Guo Xiuqing, Cui Jinrui, Quiñones Manuel J, Clee Susanne M, Yandell Brian S, Blangero John, Hsueh Willa A, Attie Alan D, Stern Michael P, Rotter Jerome I

Abstract excerpt

OBJECTIVE: A small number of susceptibility genes for human type 2 diabetes have been identified by candidate gene analysis or positional cloning. Genes found to influence diabetes or related traits in mice are likely to be susceptibility genes in humans. SorCS1 is the gene identified as responsible for the mouse chromosome 19 T2dm2 quantitative trait locus for fasting insulin levels, acting via impaired insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Mexican Americans

Share to Overweight

Share to Polymorphism, Single Nucleotide

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 17426289
DOI: 10.2337/db06-1677

Genes

SORCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse.PMID 17426289Read ↗

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivitySemantic proximity Read ↗

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivitySemantic proximity Read ↗

Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells.Semantic proximity Read ↗

Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study.Semantic proximity Read ↗

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective study.Semantic proximity Read ↗

A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1.Semantic proximity Read ↗

The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians.Semantic proximity Read ↗

A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of <i>Sirt1</i>Semantic proximity Read ↗

Gene loci associated with insulin secretion in islets from non-diabetic mice.Semantic proximity Read ↗

Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.