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Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis

17 Apr 2012

Abstract excerpt

The transcription factors HNF1B and Pax2, co-expressed in the Wolffian duct and ureteric bud epithelia, play essential roles during the early steps of mouse kidney development. In humans, heterozygous mutations in these genes display a number of common kidney phenotypes, including hypoplasia and multicystic hypoplastic kidneys. Moreover, a high prevalence of mutations either in HNF1B or PAX2 has been observed in...

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PMID: 22511595
DOI: 10.1093/hmg/dds141

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