Article
Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements.
Clinical transplantation - 1 Jan 2000
Fredericks Salim, Jorga AnaMaria, MacPhee Iain A M, Reboux Sandrine, Shiferaw Elizabeth, Moreton Michelle, Carter Nicholas D, Holt David W, Johnston Atholl
Abstract excerpt
The intestinal efflux pump P-glycoprotein (P-gp), the product of the multi-drug resistance-1 (MDR-1) gene, significantly influences the pharmacokinetics of several drugs. Ciclosporin is a substrate for P-gp and is metabolized by cytochrome P450 (CYP) 3A enzymes. P-gp activity is affected by sever...
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