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Article

The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Aug 2011

Niemiec Pawel, Nowak Tomasz, Balcerzyk Anna, Krauze Jolanta, Zak Iwona

Abstract excerpt

The CYBA gene encodes the p22phox peptide, an essential subunit of vascular NADPH oxidases. The aim of the study was to analyze potential interactions between CYBA gene A640G polymorphism and traditional risk factors of atherosclerosis. We studied 320 subjects: 160 patients with coronary artery disease (CAD) and 160 controls. The results of interactions were interpreted on the basis of synergy index values (SI,...

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Source

Identifiers

PMID: 21777168
DOI: 10.3109/1354750X.2011.580368

Genes

CAD
CYBA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia.PMID 21777168Read ↗

The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia.Semantic proximity Read ↗

The -930A>G polymorphism of the CYBA gene is associated with premature coronary artery disease. A case-control study and gene-risk factors interactions.Semantic proximity Read ↗

CYBA gene variants as biomarkers for coronary artery disease.Semantic proximity Read ↗

Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.Semantic proximity Read ↗

Relationship of the p22phox (CYBA) gene polymorphism C242T with risk of coronary artery disease: a meta-analysis.Semantic proximity Read ↗

Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study.Semantic proximity Read ↗

C242T polymorphism in CYBA gene (p22phox) and risk of coronary artery disease in a population of Caucasian Italians.Semantic proximity Read ↗

The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes.Semantic proximity Read ↗

The A640G polymorphism in the NAD(P)H oxidase p22phox gene (CYBA) is associated with risk reduction of coronary heart disease: a meta-analysis.Semantic proximity Read ↗

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