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Article

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically

7 Nov 2000

Abstract excerpt

A direct pathophysiological role of Familial Alzheimer's Disease (FAD)-associated Presenilin 1 (PS1) mutations in neuronal vulnerability remains a controversial matter. We evaluated the relationship between PS1 and excitotoxicity in four different experimental models of neurotoxicity by using primary neurons from (i) transgenic (tg) mice overexpressing a human FAD-linked PS1 variant (L286V mutation), (ii) tg mice...

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PMID: 11070093
DOI: 10.1073/pnas.97.23.12822

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