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Article

The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI*.

HIV medicine - 1 Jan 2012

Cozzi-Lepri A, Paredes, Phillips A N, Clotet B, Kjaer J, Von Wyl V, Kronborg G, Castagna A, Bogner J R, Lundgren J D

Abstract excerpt

BACKGROUND: Virological failure of first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz despite virological failure, when these drugs are used as a component of combination antiretroviral...

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Identifiers

PMID: 21848790
DOI: 10.1111/j.1468-1293.2011.00943.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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