Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.

Cancer research - 15 Apr 2007

Sasai Ken, Romer Justyna T, Kimura Hiromichi, Eberhart Derek E, Rice Dennis S, Curran Tom

Abstract excerpt

The sonic hedgehog (Shh) pathway is activated in approximately 30% of human medulloblastoma resulting in increased expression of downstream target genes. In about half of these cases, this has been shown to be a consequence of mutations in regulatory genes within the pathway, including Ptc1, Smo,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hedgehog Proteins
Share to Medulloblastoma
Share to Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Patched-1 Receptor

Share to Patched Receptors

Share to Receptors, Chemokine

Share to Receptors, G-Protein-Coupled

Share to Smoothened Receptor

Source

Identifiers

PMID: 17413002
DOI: 10.1158/0008-5472.CAN-07-0493

Genes

CXCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17413002-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.PMID 17413002Read ↗

Shh Pathway Activity Is Down-Regulated in Cultured Medulloblastoma Cells: Implications for Preclinical StudiesSemantic proximity Read ↗

Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migrationSemantic proximity Read ↗

Loss of suppressor-of-fused function promotes tumorigenesis.Semantic proximity Read ↗

Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma CellsSemantic proximity Read ↗

Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.Semantic proximity Read ↗

PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway InhibitionSemantic proximity Read ↗

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.Semantic proximity Read ↗

The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma.Semantic proximity Read ↗

Reduced tumorigenicity of rat glioma cells in the brain when mediated by hygromycin phosphotransferase.Semantic proximity Read ↗

Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growthSemantic proximity Read ↗

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Semantic proximity Read ↗

Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.