Article
The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma.
Scientific reports - 10 Jan 2020
Sarić Nemanja, Selby Matthew, Ramaswamy Vijay, Kool Marcel, Stockinger Brigitta, Hogstrand Christer, Williamson Daniel, Marino Silvia, Taylor Michael D, Clifford Steven C, Basson M Albert
Abstract excerpt
Sonic Hedgehog (SHH) medulloblastomas are brain tumours that arise in the posterior fossa. Cancer-propagating cells (CPCs) provide a reservoir of cells capable of tumour regeneration and relapse post-treatment. Understanding and targeting the mechanisms by which CPCs are maintained and expanded in SHH medulloblastoma could present novel therapeutic opportunities. We identified the aryl hydrocarbon receptor (AHR)...
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