Article
Reduced tumorigenicity of rat glioma cells in the brain when mediated by hygromycin phosphotransferase.
Journal of neurosurgery - 1 Apr 2001
Hormigo A, Friedlander D R, Brittis P A, Zagzag D, Grumet M
Abstract excerpt
OBJECT: A variant of C6 glioma cells, C6R-G/H cells express hygromycin phosphotransferase (HPT) and appear to have reduced tumorigenicity in the embryonic brain. The goal of this study was to investigate their reduced capacity to generate tumors in the adult rat brain. METHODS: Cell lines were implanted into rat brains and tumorigenesis was evaluated. After 3 weeks, all rats with C6 cells showed signs of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.