Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of P-450 IIC7 and IIIA1,2 mRNA in pre-neoplastic liver. Effect of promotion by phenobarbital.

Biochimica et biophysica acta - 23 Oct 1990

Lechner M C, Barroso M, Decloitre F, Lafarge-Frayssinet C, Ouldelhkim M, Frayssinet C

Abstract excerpt

P-450 IIC7 and IIIA2 mRNAs are constitutively expressed in the hepatic tissue under developmental control. Both forms--as well as IIIA1, 90% homologous to IIIA2 mRNA--display positive modulation by phenobarbital a prototype inducer of the liver monooxygenases and a strong promoter of experimental chemical hepatocarcinogenesis. In the present work the variations in the concentration of these P-450 mRNA were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Liver Neoplasms

Share to Phenotype

Share to RNA, Messenger

Source

Identifiers

PMID: 1699606
DOI: 10.1016/0167-4781(90)90200-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Modulation of P-450 IIC7 and IIIA1,2 mRNA in pre-neoplastic liver. Effect of promotion by phenobarbital.PMID 1699606Read ↗

Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion.Semantic proximity Read ↗

[Modulation of mRNAs P450 and hepatocarcinogenesis promotion].Semantic proximity Read ↗

Review Article: Paradoxical Effects of Phenobarbital on Mouse HepatocarcinogenesisSemantic proximity Read ↗

Phenobarbital induction of aldehyde dehydrogenase type 2 mRNA in mouse liver: a candidate region on chromosome 7 for a putative regulatory gene.Semantic proximity Read ↗

Definition of stages during hepatocarcinogenesis in the rat: potential application to the evaluation of initiating and promoting agents in the environment.Semantic proximity Read ↗

Identification and functional characterization of a cis-acting positive DNA element regulating CYP 2B1/B2 gene transcription in rat liver.Semantic proximity Read ↗

The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.Semantic proximity Read ↗

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.