Modulation of P-450 IIC7 and IIIA1,2 mRNA in pre-neoplastic liver. Effect of promotion by phenobarbital.

doi:10.1016/0167-4781(90)90200-l

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Article

Modulation of P-450 IIC7 and IIIA1,2 mRNA in pre-neoplastic liver. Effect of promotion by phenobarbital.

Biochimica et biophysica acta - 23 Oct 1990

Lechner M C, Barroso M, Decloitre F, Lafarge-Frayssinet C, Ouldelhkim M, Frayssinet C

Abstract excerpt

P-450 IIC7 and IIIA2 mRNAs are constitutively expressed in the hepatic tissue under developmental control. Both forms--as well as IIIA1, 90% homologous to IIIA2 mRNA--display positive modulation by phenobarbital a prototype inducer of the liver monooxygenases and a strong promoter of experimental...

Topics

Alpha-Globulins
Animals
Blotting, Northern
Carcinogens
Cytochrome P-450 Enzyme System
Liver
Liver Neoplasms
Male
Phenobarbital
Phenotype
Precancerous Conditions
RNA, Messenger
RNA, Neoplasm
Rats
alpha-Fetoproteins

Source

Open in PubMed

Identifiers

PMID: 1699606
DOI: 10.1016/0167-4781(90)90200-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1699606-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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