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Article

Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes.

Toxicology letters - 8 Feb 2006

Joannard Florence, Rissel Mary, Gilot David, Anderson Alan, Orfila-Lefeuvre Luz, Guillouzo André, Atfi Azzedine, Lagadic-Gossmann Dominique

Abstract excerpt

Phenobarbital (PB) alters expression of numerous hepatic genes, including genes of cytochrome P450 2B1 and 2B2 (CYP2B). However, the intracellular mechanisms remain to be fully elucidated. The present study investigated the involvement of mitogen-activated protein kinases (MAPKs) in rat hepatocytes in primary culture. We showed that PB induced an early, dose-dependent activation of ERK (extracellular...

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PMID: 16154717
DOI: 10.1016/j.toxlet.2005.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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