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Article

Filaggrin null alleles are not associated with psoriasis.

The Journal of investigative dermatology - 1 Aug 2007

Zhao Yiwei, Terron-Kwiatkowski Ana, Liao Haihui, Lee Simon P, Allen Michael H, Hull Peter R, Campbell Linda E, Trembath Richard C, Capon Francesca, Griffiths Christopher E M, Burden David, McManus Ross, Hughes Rosalind, Kirby Brian, Rogers Sarah F, Fitzgerald Oliver, Kane David, Barker Jonathan N W N, Palmer Colin N A, Irvine Alan D, McLean W H Irwin

Abstract excerpt

Psoriasis is a common skin disease with an etiology consistent with a multifactorial trait. Several psoriasis susceptibility loci are known, a number of which are also implicated in a predisposition to atopic dermatitis (AD), including the epidermal differentiation complex on chromosome 1q21. It...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17410197
DOI: 10.1038/sj.jid.5700817

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17410197-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Filaggrin null alleles are not associated with psoriasis.PMID 17410197Read ↗

Lack of association between filaggrin gene mutations and onset of psoriasis in childhood.Semantic proximity Read ↗

Loss-of-function variants of the filaggrin gene are not major susceptibility factors for psoriasis vulgaris or psoriatic arthritis in German patients.Semantic proximity Read ↗

Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic EczemaSemantic proximity Read ↗

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.Semantic proximity Read ↗

Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study.Semantic proximity Read ↗

The filaggrin null genotypes R501X and 2282del4 seem not to be associated with psoriasis: results from general population study and meta-analysis.Semantic proximity Read ↗

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.Semantic proximity Read ↗

Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.Semantic proximity Read ↗

Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood.Semantic proximity Read ↗

Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma.Semantic proximity Read ↗

Common filaggrin gene loss-of-function variants are associated with skin cancer risk.Semantic proximity Read ↗

The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients.Semantic proximity Read ↗

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