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Article

Filaggrin null alleles are not associated with psoriasis.

The Journal of investigative dermatology - 1 Aug 2007

Zhao Yiwei, Terron-Kwiatkowski Ana, Liao Haihui, Lee Simon P, Allen Michael H, Hull Peter R, Campbell Linda E, Trembath Richard C, Capon Francesca, Griffiths Christopher E M, Burden David, McManus Ross, Hughes Rosalind, Kirby Brian, Rogers Sarah F, Fitzgerald Oliver, Kane David, Barker Jonathan N W N, Palmer Colin N A, Irvine Alan D, McLean W H Irwin

Abstract excerpt

Psoriasis is a common skin disease with an etiology consistent with a multifactorial trait. Several psoriasis susceptibility loci are known, a number of which are also implicated in a predisposition to atopic dermatitis (AD), including the epidermal differentiation complex on chromosome 1q21. It has recently been shown in several replicate studies that prevalent null alleles for the filaggrin gene (FLG) on 1q21...

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Source

Identifiers

PMID: 17410197
DOI: 10.1038/sj.jid.5700817

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Filaggrin null alleles are not associated with psoriasis.PMID 17410197Read ↗

Lack of association between filaggrin gene mutations and onset of psoriasis in childhood.Semantic proximity Read ↗

Loss-of-function variants of the filaggrin gene are not major susceptibility factors for psoriasis vulgaris or psoriatic arthritis in German patients.Semantic proximity Read ↗

Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic EczemaSemantic proximity Read ↗

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.Semantic proximity Read ↗

Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study.Semantic proximity Read ↗

The filaggrin null genotypes R501X and 2282del4 seem not to be associated with psoriasis: results from general population study and meta-analysis.Semantic proximity Read ↗

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.Semantic proximity Read ↗

Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.Semantic proximity Read ↗

Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood.Semantic proximity Read ↗

Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma.Semantic proximity Read ↗

Common filaggrin gene loss-of-function variants are associated with skin cancer risk.Semantic proximity Read ↗

The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients.Semantic proximity Read ↗

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