Article
Lack of association between filaggrin gene mutations and onset of psoriasis in childhood.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Jan 2013
Winge M C G, Suneson J, Lysell J, Nikamo P, Liedén A, Nordenskjöld M, Wahlgren C F, Bradley M, Ståhle M
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD; OMIM#603165) and psoriasis (OMIM#177900) are two common inflammatory skin disorders. Both are genetically complex, multifactorial and do not follow a Mendelian pattern of inheritance. Both diseases share several genetic susceptibility loci such as the epidermal differentiation complex (EDC) on chromosome 1q21. Within the EDC, mutations in the filaggrin (FLG) gene are strongly...
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