Article
The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients.
Acta dermato-venereologica - 6 Apr 2017
Luukkonen Tiia Maria, Kiiski Ville, Ahola Maria, Mandelin Johanna, Virtanen Hannele, Pöyhönen Minna, Kivirikko Sirpa, Surakka Ida, Reitamo Sakari, Palotie Aarno, Heliövaara Markku, Jakkula Eveliina, Remitz Anita
Abstract excerpt
The contribution of filaggrin null mutations to predicting atopic dermatitis (AD) treatment response is not clear, nor have such mutations been studied in the Finnish population. This study tested the association of the 4 most prevalent European FLG null mutations, the 2 Finnish enriched FLG null mutations, the FLG 12-repeat allele, and 50 additional epidermal barrier gene variants, with risk of AD, disease...
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